بررسی اثرات 4 نوع عصاره میوه آووکادو بر روی رده سلول های اسکواموس کارسینوم مری در مقایسه با سلول های تک هسته ای خون محیطی و گروه کنترل

Background and purpose: The majority of patients with cancers of the digestive system admit themselves to the health care systems in the final stages of the disease and conventional treatments do not have a major impact on the prognosis in these patients. Therefore, utilization of new methods of treatment with lower adverse effects can cause higher survival rates. In this study, the in vitro effects of 4 avocado extracts on esophagus squamous cell carcinoma in comparison with peripheral mononuclear blood cells have been evaluated. Materials and methods: In an experimental study, after acquiring alcoholic, chloroform, ethyl acetate and petroleum avocado fruit (Persea Americana) extracts, their effects on squamous cell carcinoma of the esophagus cell growth were compared with controls in cell culture using MTT method. Results: The results from this study on esophageal squamous cell cancer shows an inverse linear relationship between the concentrations of living cells there are avocado extract. Furthermore, results show that avocado fruit extract play an inhibitory role on the growth of cancerous cells in comparison with normal cells (p<0.05). Conclusion: Avocado fruit is a rich source of phytochemicals which shows an effective role in inhibition of cancer cell growth. This study demonstrates its effectiveness in esophageal cancer for the first time. Usage of the extract of this fruit, it seems, can be a supplementary treatment in esophagus cancers.